RINKEL:What kind of sounds are you talking about? Is it just music, or sound effects too?
I personally have my computer on mute unless listening to music or watching a video because the sounds annoy me (I can't even bear the start-up noise so I leave it on standby all the time), so if you do add sounds you'd have to have something that states there are sounds, because if there isn't and I check out your comic, unless I've got something playing in the background and your sounds interfere I'm not going to know there are sounds.
And what about the kind of music? If you have several different things going on in one page, like a really happy panel then all of a sudden a really sad panel (because something happened to a character) you'd have to get music that changes quickly, but you'd also have to factor in the individual reading pace of other people. And if things change radically from one page to the next if the reader is a fast reader like I am they'd only hear a little snippet of the music for one page before going to the next.
I'm not trying to dash your hopes of an audio-involved comic (I actually think it's a cool idea), I'm just trying to point out a few things you'd have to take into consideration.
If I were to do this I would probably have a splash page with the character playing the song in question.
