Yeah, there's not many chances of going pro in this economy where there aren't many comic stores (like there were a few decades ago) and book stores are closing left and right. You can always submit to small press publishers and Image as well.
Marvel an DC aren't looking for unknowns so much with all the unemployed pros to choose from.
Self publishing is cheap but is not a guarantee that you'll get a lot of readers.
You might have more luck doing graphic novels. It just takes persistence.